Sirtuin 1 and Sirtuin 2 Plasma Concentrations in Patients with Ascending Aortic Dissection and Ascending Aortic Aneurysm

Abstract Background Previous studies explored multifactorial interactions and sirtuin expression in the aortic cells of laboratory rodents humans. Human were limited due to availability biological material exclusively advanced stage disease. The role sirtuins pathology has not been explained extensively therefore aim study was assess plasma concentrations human 1 (SIRT1) 2 (SIRT2) patients with ascending dissection aneurysm. Material methods group included 43 adults (34 males 9 females) aged 44–92 years ( n = 10) or aneurysm 33). SIRT1 SIRT2 patients’ blood samples determined, differences between groups observed p 0.02 for SIRT1, 0.04 SIRT2). Results Levels both lower (SIRT1: median 6.5 ng/mL; SIRT2: 5.7 ng/mL) than 9.2 7.8 ng/mL). cut-off levels differentiating 6.7 ng/mL 3.2 ng/mL, respectively. Conclusions had Calculated values enzymes may be helpful differentiation from